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A patient with end-stage renal disease presented with a rare episode of bacterial endocarditis 2 months after he received a kidney transplant. In addition to intravenous antibiotics, the patient underwent surgical management that included the removal of the infected native aortic valve and the replacement with a mechanical valve. The patient recovered and was discharged home on antibiotics after 2 weeks of intensive care monitoring. Follow-up at 6 months showed no evidence of infection.Bispecific antibodies (BsAb) can achieve better B cell activation/stimulation and antibody production as compared to conventional monoclonal antibodies. BsAb is potentially effective in promoting a safe and efficacious immune response. It can be used in the treatment of a range of diseases including cancer and infectious diseases. BsAb is a combination of a target-specific single chain antibody fragment and an effector chain, which are linked with a non-covalent disulfide bond. BsAb has a dual specificity for the target and the effector chain, providing both a direct effect by activation of effector cells, and indirect activation by signal transduction. BsAb can be administered systemically and does not require the extra time or money for manufacturing and production.
Functional monovalent bispecific antibodies (functional BsAb) are key components of bispecific antibodies (BsAb). Compared to BsAb, functional BsAb allows for flexibility in linking the effector cells to the target cell and has lower toxic effect in vivo. However, BsAb remains to be more effective in therapeutic application as it needs to be more stable to retain its activity and has reduced side effect than the functional BsAb. To the contrary, the production of functional BsAb is more difficult.
Rigid diabodies are modular proteins that can be expressed in bacteria and eukaryotic cells. Diabody is constructed from the light chain variable domain of an antibody and the heavy chain constant domain of an antibody. The two 0b46394aab
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